49ers @ Colts: 5 Bets for Week 16
The Battle of New Dads vs Granddads
OK, the subtitle might be a little misleading, just one grandad. The 49ers touched down in Indianapolis this weekend for what profiles as a bizarre one. Potbelly and all we got the best version of what we could have hoped for from ol’ Phillip Rivers in week 15. His arm didn’t look lively per se, but the mind was sharp as he dissected coverage against one of the best defenses in the NFL. What we will get in week 16 is hard to predict. Here goes nothing, your week 16 49ersHub bets (Via @DKSportsbook):
Season Record: 31-18-1
49ers Cover -5.5 (-105): We have only gone to the spread well a couple times this year but have hit when we do. We’re going back once more. Rivers’ return is an amazing story, but amazing stories should not affect how we bet. They do, however, affect how the public bets. Despite only getting 58% of the total number of bets placed, as of Friday 70% of the dollars bet were on San Francisco. What does that mean? The sharp (big) money likes the 49ers. If this were any other third string quarterback we wouldn’t think twice about it, I love them to cover in Indy.
Tyler Warren U 38.5 Receiving Yards (-112): Warren has only cleared this total once in the last month, and not since the QB play declined after the Daniel Jones injury. The 49ers hemorrhage production to the tight end position, so I understand the temptation to take the over with one of the more talented prospects the position has ever seen but the under feels like the right move given the circumstances.
Look for SF to crowd the box and try to force Rivers to push the ball down the sidelines or over the top, that spells a Warren under to me.
Brock Purdy O 247.5 Passing Yards (-111): Can we make it three weeks in a row of hitting the Brock Purdy passing total? Under against Cleveland, over against the Titans, and we’re going over here again. Indianapolis is missing both their corners in what has been a pass funnel defense most of this year as it is, they are top 5 in rush EPA on that side of the ball. Even if the 49ers take a decent lead, the best avenue to sustaining drives likely comes through the air on Monday night.
Jauan Jennings O 4.5 Receptions (-116): With Pearsall out this week for the 49ers, as well as Charvarius Ward and Sauce Gardner out for the Colts, it feels like a great spot to bet on a 5 reception game for Jennings. Jennings has done great work when thrust into the X receiver role over the last two seasons. As he’s gotten healthier in 2025 we have seen more of the same, particularly in the red-zone.
If you feel like doing some big game hunting tonight, a Jennings same game parlay on DK would pay out +320. That’s over 4.5 receptions, over 55.5 yards, and an anytime touchdown. I don’t hate it at all, but the receptions are the safest bet there for me.
Eddie Pineiro O 1.5 FGs Made (-153): Don’t accuse me of being lazy for including this two weeks in a row! Don’t accuse me of being biased because I’m a huge Eddie Pineiro fan and have him all over in fantasy. Forget the fact that I have said Pineiro props are my favorite things to include in these articles. This is well reasoned, impartial betting here.
We have not missed a kicking prop this season and I do not intend to against the Colts. They just allowed Jason Myers to kick 6/6 in Seattle last Sunday. With their two top corners down and this defense leaking oil, yards should not be hard to come by for Kyle Shanahan. Odds are, at least two drives come down to Eddie’s leg. Into the Eddie frey we go, once more.
Good luck this week everyone, let’s hope we can keep the hit rate above 60% in a game that has a hilariously broad range of outcomes. I’ll be in the trenches sweating it out with all of you!