The Best 5 Prop Bets for 49ers/Jaguars
The Forecast: RB’s Go Wild
There is nothing better than getting paid to sit on your couch and watch football. Let’s look for the best routes to take with Sunday’s prop bets, ahead of a pivotal matchup with Jacksonville.
Trevor Lawrence under 226.5 passing yards -114 (FanDuel)
There is valid concern here that should the Niners take a sizable lead the Jaguars could abandon the rush. However, Trevor only surpassed this yardage total 3 times in 10 games in 2024, and just 1 out of 3 in 2025. Their passing game looks broken, for a multitude of reasons, so it does not feel like this matchup with a defense allowing 172 passing yards per game is where he spikes. Additionally, Jacksonville has only been successful on 19% of passing plays when the QB is pressured since 2024, well below the league average of 31%. Lawrence faces a pass rush which pressures at 42.54%. Thanks in large part to Robert Saleh’s timely blitzing. We can expect to see more of it come Sunday.
Travis Etienne over 52.5 rushing yards -114 (Fanduel)
A trend that will continue throughout these picks is correlating calls with what this projected game script will be. Despite the sizable 46.5 over under, these are two stout defenses matching up, ranked 4th and and 10th in total yardage allowed. The 49ers are the 13th best rushing defense with Nick Bosa. Without him there should be more room to run, and exploit their longstanding vulnerability to the ground game. Jacksonville currently generates the second most yards before contact per rush, which has led to Etienne averaging 90 yards per game. 52.5 feels like a comfortable number to take here.
Christian McCaffrey over 42.5 receiving yards -114 (DraftKings)
CMC is averaging 71 receiving yards per game in 2025. In their only outing together he saw 10 targets from Purdy, tallying 9 grabs for 73 yards. In the two subsequent games he posted 7/6/52 and 15/10/88. Close to even odds on 42.5 feels like stealing here, especially against an opportunistic Jacksonville defense that has been picking balls off left and right. Look for Kyle and Co. to call a conservative game plan and protect the ball. With no Kittle or no Jauan, fire up that over.
Christian McCaffrey under 73.5 rushing yards -114 (Fanduel)
This is correlated with the receiving prop in that the 49ers line has not generated much push early on here in 2025. Cornerstone Trent Williams has looked less than healthy, and first year standout Dominick Puni has not been great either. Both are likely dealing with nagging issues after popping up on August injury reports off and on.
One way they have worked around that is to have short routes to the running back operate as an extension of the rushing game. Christian has so far totaled 52, 55, and 69 rushing yards. He only broke this figure (73.5) once in 4 games last year as well. We are projecting the receiving usage to continue for this game. Add into that equation the Jags’ 4th ranked rushing defense (82.7 yards per game allowed) and this is an easy take for me.
For you Big Risk Folks: Christian McCaffrey and Travis Etienne to each record 5+ rushing yards in each quarter +470 (FanDuel)
In keeping with the projected game script, a more conservative one, I absolutely love this. Travis Etienne’s average rush yards per quarter in 2025 have been; Q1 7.7, Q2 43.3, Q3 10.3, Q4 28.7. For CMC it’s 15.3, 13, 21, and 9.3 respectively. The Jaguars defense has produced 7 interceptions through 3 games, and the 49ers currently allow the 4th fewest passing in the league. Both coaches will be inclined to dial up plenty of first down runs. Call me a sucker for loving what essentially amounts to an 8 leg parlay, but you could do a whole lot worse for +470.