The 5 Best Prop Bets for 49ers/Cardinals
The Exciting Showdown of the Injured vs the More Injured
Another week, another betting slate. We are coming in hot off the first 5-0 finish of the season, what I have dubbed our white whale of this segment. It brings us to 20-9-1 on the year.
This week is the face off of wheelchairs and crutches, as two banged up NFC West foes meet in the desert. It’s the latest iteration of what’s always been a highly competitive matchup with Jonathan Gannon at the helm for the Cardinals. Brock Purdy is back! So is Rickey Pearsall. Vibes are high headed into State Farm Stadium, hopefully the ROI is too. Here are your Week 11 49ersHub bets (via @DKSportsbook).
49ers -3 (-118)
We are playing the spread for the first time this year, and that is because the number is too manageable to pass up. The 49ers have been rock solid ATS on the road in 2025, going 4-2 (5-5 overall). This is no cupcake against the perpetually undervalued Cardinals. They are a quiet wagon in their last 20, 13-7 ATS. This year they’ve only managed one cover in four home games though.
Jacoby Brissett will be on the sticks for their offense, an offense which is now devoid of Marvin Harrison Jr. following his mid-week appendectomy. They are without their two best running backs as it is, and have another 8-10 players listed as questionable. I know the Niners defense has been down bad, baaaaad. But this is laying a field goal in a very soft matchup. Maybe it pushes off the bad number, but pushes don’t lose money. Hammer SF -3 here.
Trey McBride 8+ Receptions (-101)
Boy do I get nervous seeing such a monster total next to a tight end’s name, but it’s warranted in this case. In their four games together since Brissett took over, Trey has eclipsed this figure in three of them. He’s been the highest producing TE in the league during that span. Now he gets a vulnerable 49ers secondary which relinquishes the 13th most receiving yardage to the position. A secondary which has also been enduring particularly atrocious linebacker coverage over the last month and a half.
Passing will be aplenty in a 48.5 O/U game. We’ll take the man who projects to be the most featured pass catcher across either team to hit the usage over. If you’re feeling extra spicy and wanna parlay this with his anytime TD prop at -120, the parlay would payout +265 and I think that’s fantastic value. Opposing TE’s have scored on SF each of the last two weeks.
Michael Wilson 5+ Receptions (+137)
Wilson has been a fixture in all my DraftKings daily fantasy lineups this week, and I am streaming him in a few high stakes redraft fantasy leagues as well. He profiles as their clear WR1 on Sunday. Going against the team that he had his career best showing against in 2023 (7-76-2).
Over the last month SF has been the second worst overall pass defense, to add to that Deommodore Lenoir enters the game questionable with a calf injury. This is a great plus money number in a favorable game script, at home against one of the least effective pass rushes and defenses in the NFL. We’re going in on it.
Jauan Jennings o3.5 Receptions (-129)
This has been another regular bet in this segment, for good reason. Jauan continues to see great usage as he gets healthier week to week, as he’s one of Brock Purdy’s most trusted targets. He’s also caught four or more passes for a month straight. We are going to approach the 49ers injury report with a healthy dose of skepticism in regards to Rickey Pearsall being a full go. Whether he is or isn’t, 3.5 is too low. We’re riding third-and-Jauan once more into the fray.
Christian McCaffrey o49.5 Receiving Yards (-110)
That’s right folks, back for its weekly appearance, the CMC receiving prop over. I’m sorry. I cannot in good conscience tell you people to leave free money on the ground for the sake of making myself look sharper. This prop would have been cleared in 9/10 games in 2025. That is absurd consistency.
We did take an L on it a few weeks back, but a 90% hit rate is just so so good. Brock Purdy stated he’s playing with no shoe insert or limitations this week, maybe that’s the case, maybe it isn’t. You never know with 49ers injury reporting. Coming off a major malady in whatever condition he may be in, it makes a ton of sense to be prudent by having less scrambles and more dumpoffs in the gameplan. Like Dad’s Thanksgiving stuffing, Mom’s Christmas cookies, giving your old shaky dog a hug, this just feels like home to me. I love it.
A parlay with his receptions over, at 5.5 (+114) would pay out +309. I like this one even better than the McBride parlay, and it pays more as well.
That’s going to wrap the week 11 49ersHub bets. To those of you who have been following along this season, I hope it has been an enjoyable ride. 66.7% of these have come home, the pressure is on to keep it rolling. Good luck to everyone, and good luck to Brock and the boys in his return!